...-4-26固体分散体及其片剂的研究 于月梅 【摘要】： 本文以XL-4-26为模型药物,进行固体分散体( System of Solid Dispersions, SD)及片剂的研究。
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方法：采用溶剂法制备固体分散体，进行溶解度、溶出速率测定，导数热重分析(DTG)。
Methods: the solid dispersion was prepared by solvent method. The solubility, the dissolution rate and the derivative thermogravimetry (DTG) were determined.
方法：以聚乙烯吡咯烷酮（PVP）、聚乙二醇-6000（PEG-6000）为载体，溶剂法和溶剂熔融法制备固体分散体，并进行体外溶出度研究。
Method: carvedilol solid dispersions were prepared by solvent-melting and coevaporation methods with PEG-6000 and PVP as carriers, the study on the dissolution was conducted in vitro.
方法：将冰片用水溶性辅料聚乙二醇6000制成固体分散体，并填装入胶囊，进行毒理试验。
Method: Bomeolum Syntheticum and PEG 6000 mixing preparative solid dispersion and packed capsules, toxicity was tested.
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