...分子、胶态、微晶或无定形状态,高度均匀分散在水溶性、难溶性或肠溶性固态载体物质中形成药物-载体固体分散体(Solid dispersion,SD)的制剂技术,目前主要用于增加难溶性药物的溶出,提高生物利用度.
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目的：考察水溶性联合载体在增加难溶性药物的溶出速率上是否优于单一载体，并制备速释型固体分散体。
Objective: to investigate whether the combined carrier is superior to the single carrier in improving dissolution of poorly insoluble water drug and prepare a fast released solid dispersion.
方法：以聚乙烯吡咯烷酮（PVP）、聚乙二醇-6000（PEG-6000）为载体，溶剂法和溶剂熔融法制备固体分散体，并进行体外溶出度研究。
Method: carvedilol solid dispersions were prepared by solvent-melting and coevaporation methods with PEG-6000 and PVP as carriers, the study on the dissolution was conducted in vitro.
载体为PVP所制固体分散体的体外溶出行为总体优于载体为PEG - 6000的固体分散体。
The in vitro dissolubility of solid dispersions with PVP as carrier was faster than that of solid dispersions with PEG-6000 as carrier.
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