其与DNA结合的功能域(motif)的结构特点是转录因子的结合位点(transcription factor binding site,TFBS)是转录因子调节可见GC盒两侧的顺序对Sp1-GC盒的结合究竟如何能影响转录。
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目的:预测人类BMP - 2基因启动子位置和可能的转录因子结合位点。
Objective: to predict the promotor position and transcription factor binding sites of human BMP-2 gene.
转录因子与其结合位点的结合具有高度的专一性。
The union of the transcription factor and corresponding binding sites has the high specificity.
目前,已经有大量的方法用于识别转录因子结合位点,大致可分为基于保守模体和比较基因组学两种方法。
There are a large number of methods for identifying transcription factor binding sites, and it can be divided into two ways: conservative motif based and comparative genomics.
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