前言： 近年来，一些不依赖于转录因子活性的新型双杂交系统相继建立，如分离的泛素系统、 蛋白质片段互补分析、 阻遏物重构分析和SOS恢复系统等。

Some new type of two-hybrid systems, such as split-ubiquitin system, protein-fragment complementation assay, repressor reconstitution assay and SOS recruitment system, have been developed recently.

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自然界中有一类名为转录因子的蛋白可调节(升高或者降低)基因的活性，该技术正是基于该机理。

The technique relies on a natural process by which the activity of genes is raised or lowered by proteins called transcription factors.

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作为端粒酶活性的关键决定因子，端粒酶逆转录酶的调控研究已取得了重大进展，但具体机制仍不清楚。

As a critical factor of telomerase activity, much progression has been achieved in the study of regulation of human telomerase reverse transcriptase, but the detail mechanism is still not clear.

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