【Key words】 Salt-sensitive hypertension; Amlodipine; Eplerenone; Podocyte injury; Renal hypoxia; Chronic renal inujury;
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Podocyte Injury caused by MR Upregulation and ActivationIn rats receiving a high-salt diet,glomerular expressions of podocin and nephrin were markedly decreased,whereas expression of a damaged podocyte marker desmin was upregulated.
5.MR激活导致的足细胞损伤高盐饲料喂养DS大鼠肾小球podocin和nephrin表达显著降低,然而desmin表达却显著升高。
参考来源 - 氨氯地平和依普利酮联合应用在缓解盐敏感高血压所致肾脏损害中作用机制的研究·2,447,543篇论文数据,部分数据来源于NoteExpress
目的探讨新生小鼠中足细胞损伤对肾小球发育的影响及其机制。
Objective To study the effect of injured podocytes on glomerular maturation and its underlying mechanism in neonatal mice.
目的 探讨全反式维甲酸(ATRA)对糖尿病大鼠足细胞损伤的保护作用。
Objective To investigate the protective effect of all-trans retinoic acid (ATRA) on podocyte lesion in diabetic rats.
结论:ORG患者存在足细胞损伤,并表现出足细胞相对密度下降和绝对数目减少两种类型。
Conclusion:A relative decrease of the density and an absolute decrease in the number of podocytes was observed in ORG patients, and varied at different stage of the disease.
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