异常的表观遗传重编程是克隆胚胎发育失败的一个重要因素。
One critical factor of these developmental failures of cloned embryos is the aberrant epigenetic reprogramming.
供体细胞核移入去核的卵母细胞后，必定要经过表观遗传修饰的重编程过程，回到胚胎开始发育的全能状态。
The donor nucleus must experienced the epigenetic modification of the process reprogramming and went back to the initial state after the donor cell was injected into the oocytes.
本文主要从转录因子、表观遗传和信号转导等角度，介绍了细胞重编程分子机制研究方面的进展和未来的方向。
In the present paper we review the role and molecular mechanism of transcription factors, epigenetic regulation and cell signaling in cell reprogramming.
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