运用高效液相色谱法检测药物浓度，计算其表观渗透系数。
The drug concentration was determined by high performance liquid chromatography(HPLC) to calculate the apparent permeability coefficient.
结果表明，膨润土饱和渗透系数的变化是由表观孔隙率和凝胶体蒙脱石层间距离的共同作用引起的。
It is shown that the changes of is resulted from the changes of both apparent porosity and the distance between layers of gel-type montmorillonite in interparticle pores.
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