用HPLC法测定血清药物浓度。
证实采用常规给药方法血清药物浓度较高且持续时间短,包埋缓释药物血清浓度较低、持续时间较长。
The serum drug is higher and shorter time by the routine methods. The serum concentration of FT-207 is lower and retarded by implanted.
减量重复给药后发现,随着第二次给药剂量减少,脑组织中药物浓度与血清药物浓度的比值下降至0.7,近似可接近单次给药后的比值。
In repeated dose decreasing group, the CZP concentration ratio in both brain and serum declined to 0.7 with the dose decrease, almost the same as that of single-dose group.
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