采用高效液相色谱(HPLC)测定硬膜外给药后血浆药物浓度。
High performance liquid chromatography (HPLC) was used to measure the plasma concentrations of local anesthetics following epidural administration.
化合物b 5、D2和D6在脑中的药物浓度与同时间的血浆药物浓度无明显差异。
The concentrations in brain and in plasma for compounds B5, D2, D6 demonstrated no significant differences.
血浆蛋白的结合作用会影响药物的分布，并影响药理活性和总血浆药物浓度间的表观关系。
Plasma protein binding influences distribution and the apparent relationship between pharmacologic activity and total plasma drug concentration.
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