其原因在于存在于合成物表面的PEG链能起到防护层的作用，进而抑制了由于非特异性蛋白质的吸附而引起的聚集反应。

This was attributed to the PEG chains present on the surface of complexes that could work as a protective shield layer against aggregation caused by non-specific protein adsorption.

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PLGA表面对蛋白质药物的非特异性吸附也会导致部分DGR的失活。

The main factors resulting in the denaturation of encapsulates DGR included the acidic microenvironment and non-specific adsorption of DGR to PLGA surface.

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