方法选用7 株丝状真菌为转化菌株,利用液相色谱质谱联用技术对药物代谢产物进行检测。
Method Metabolites produced by 7 filamentous fungi screened were identified by liquid chromatography-tandem mass spectrometry (LC-MSn).
结论该方法灵敏、快速、简便、有效,适合于生物样品中的药物及其代谢产物的快速鉴定。
Conclusion This method is sensitive, rapid, simple, effective, and suitable for the rapid identification of drug and its metabolites in biologic samples.
综述了目前HPLC-NMR联用技术在药物代谢研究,天然产物分析以及食品分析等方面的应用。
The application of HPLC-NMR in drug metabolism, natural products analysis and food analysis were reviewed.
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