超嗜热酶APE1547与脯氨酰寡肽酶(prolyl oligopeptidase,POP)家族成员有很高的同源性,具有两个结构域分别是N端的β-推进器结构域和C端的α/β催化结构域。
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与脯氨酰寡肽酶 prolyl oligopeptidase
属于脯氨酰寡肽酶家族 Prolyl oligopeptidase
脯氨酰寡肽酶抑制作用 prolyl oligopeptidase inhibitory activity
目的综述脯氨酰寡肽酶抑制剂的构效关系、天然活性成分以及临床研究等方面的进展。
Objective to review advances of the study on prolyl oligopeptidase inhibitors, including evaluation of their structure-activity relationships, natural active constituents, and their clinical studies.
方法根据国外相关文献，对脯氨酰寡肽酶抑制剂的构效关系、天然活性成分以及临床试验情况进行整理和归纳。
Method By the international literature, the structure-activity relationships of prolyl oligopeptidase inhibitors, natural active constituents, and clinical studies were summed up.
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