乏氧肿瘤细胞对放射治疗、化学治疗的耐受性增强。
Hypoxic tumor cells exhibit increased resistance to radiotherapy and chemotherapy.
乏氧肿瘤细胞的存在是患者恶性肿瘤治疗失败、复发和转移的重要原因之一。
The existence of hypoxic cells is one of the most important reasons for treatment failure, relapse and metastasis.
生物还原剂是一种具有肿瘤乏氧靶向性的前药，它会在还原性环境中被还原产生具有细胞毒性的代谢物。
Bio-reductive drugs are pro-drugs that can selectively target the hypoxia cells in tumors. In reductive environment, they are reductively metabolized to generate toxic species.
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