与真核细胞的细胞周期呈同步周期性浓度升降的蛋白质,最先是从海胆胚胎中分离鉴定的,为相对分子质量50000蛋白质的一大家族,包括:周期蛋白质A、B、D、E、G及H。它们与关键的蛋白质激酶(细胞周期蛋白依赖性激酶,cyclin-dependent kinases,CDKs)结合,并调节它们的酶活性,从而帮助推动和协调细胞周期的进行。
生物学中的许多现象如细胞凋亡、细胞周期调控、信号转导和癌变等均受蛋白质间相互作用的调控。
Many phenomena in biology, such as apoptosis, cell cycle control, signal transduction and canceration and etc, are all regulated by the interaction of proteins.
方法利用免疫细胞化学,蛋白质印迹法,RT - PCR和流式细胞术等方法分析细胞周期和对与细胞周期相关的基因表达进行研究。
Methods the cell cycle and the expression of related genes were analyzed by the methods of immunocytochemistry, protein blotting, RT PCR and flow cytometry.
泛素- 蛋白酶体通路介导细胞蛋白质的降解,在细胞周期、 基因转录及表达、 抗原提呈和炎症演进等方面发挥调控作用。
Ubiquitin-proteasome pathway mediates the degradation of cell protein and modulates cell cycle, gene translation and expression, antigen presentation and inflammation development.
It turns out in the case of Hepatitis B, the way the lifecycle proceeds-- the cells make too much of the protein and not all of it gets assembled into the virus.
结果显示,在乙肝的病案中,病毒生命周期的发展情况,细胞制造了大量的蛋白质,但并不是所有的蛋白质都会组合成病毒
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