目的：探讨苯那普利对糖尿病大鼠肾组织细胞周期蛋白激酶抑制剂p 21 CIP1蛋白表达的影响。
To investigate the effect of benazepril on expression of cyclin kinase inhibitor P21 CIP1 protein in renal tissue of diabetic rats.
细胞周期调控机制的核心是一组蛋白激酶。
The core of cell cycle regulation and control mechanism are relative to a group of protein kinase.
p 53的激活能够引起细胞周期捕获和DNA修复或细胞凋亡(1)。离体或者在体情况下，p 53可以在多个位点被几个蛋白激酶进行磷酸化(2,3)。
Activation of p53 can lead to either cell cycle arrest and DNA repair or apoptosis (1). P53 is phosphorylated at multiple sites in vivo and by several different protein kinases in vitro (2, 3).
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