原癌基因的突变导致的过度刺激细胞周期，而突变的肿瘤抑制基因，会导致在这一功能的控制过度活动。
Oncogenes are mutations that cause an excessive stimulation of the cell cycle, while mutations in tumor suppressor genes can result in a loss in function in controlling this excessive activity.
PHB1是一个30kda的肿瘤抑制蛋白，参与细胞周期控制(1)。
PHB1 is 30kda tumor suppressor protein involved in cell cycle control (1).
E2F转录因子是控制细胞周期的关键调控因子。
The E2F transcription factors are key regulators in cell cycle regulation.
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