现认为，胰岛素抵抗(IR)导致的胰岛素信号通路异常，高血糖引发的糖化终末产物(advanced glycation end-products，AGEs)的形成与堆积，β-淀粉样蛋白(β-amyloid protein，Aβ)的沉积，Tau蛋白的过度磷酸...
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产物经一系列分子重排、脱氢和断裂反应，产生不可逆的晚期糖化终末产物（advanced glycation end production, AGE）。
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...雌二醇（17β-estrodiol)对成骨细胞增殖分化的影响及雌激素（estrogen)与晚期糖化终末产物（advanced glycosylation end-product,AGE)共存对成骨细胞的作用。
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晚期糖化终末产物 advanced glycosylation end product ; advanced glycation end products
非酶糖化终末产物 advanced glycation end-products
糖基化终末产物 AGES ; advanced glycation end products ; advanced glycosylation end products ; advanced glycated end-products
糖化终末产物受体 receptor for advanced glycation end-produts
晚期糖基化终末产物 AGES ; AGE ; advanced glycation end products ; advanced glycosylation end products
发现晚期糖化终末产物 AGES ; Advanced glycation end-products
与晚期糖化终末产物 advanced glycosylation end-product
和非酶糖化终末产物 advanced glycation end products
的非酶糖化终末产物 advanced glycation end-products
目的探讨缬沙坦对糖尿病大鼠肾脏糖化终末产物受体(RAGE)表达的影响，探索其肾保护机制。
Objective to investigate the effects of valsartan on the expression of receptors for advanced glycation end-products (RAGE) in kidneys of diabetic rats, and to explore its renoprotection mechanisms.
L-1剂量范围内均可有效抑制蛋白糖化终末产物的生成，当药物浓度达2.0 g·L-1时其抑制作用相当于同剂量的氨基胍。
The inhibitory effects of EGB and EGS (2.0 g·L-1) on the generation of AGEs were almost the same as that of aminoguanidine at the same concentration.
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