目的观察小鼠烧伤后早期类固醇受体辅活化子（SRC）蛋白表达的时相变化，初步探讨烧伤早期糖皮质激素抵抗的分子机制。

Objective To observe the changes of expression of steroid receptor coactivators(SRC) during the early stage in the burned mice, and the mechanism of glucocorticoid resistance(GCR).

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大多数雄激素非依赖性前列腺癌均高表达AR和核受体辅活化子、如转录中间因子2（TIF-2），ARA24、PIAS、类固醇受体辅活化子-1（SRC-1）等有力地支持了这个假说。

The "superactive AR"hypothesis was supported by the fact that the majority of AIPC expresses high level of AR and nuclear receptor(NR) coactivators, such as TIF-2, ARA24, PIAS, SRC-1.

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