方法:切断老年SD大鼠左侧穹窿海马伞(fimbria-fornix,FF),侧脑室注射NGF,用Morris水迷宫和Y迷宫测试正常组、损伤组和治疗组大鼠的学习记忆能力。
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结论切断穹窿海马伞可引起动物学习记忆障碍。
Conclusion Fimbria fornix transection lesion can results in rats learning and memory disorder.
双侧穹窿海马伞对照组仅切断双侧穹窿海马伞浅层的皮质组织。
In FF control, the cortical tissue of the superficial layer of bilateral fimbria-fornix was transectioned.
结论：穹窿海马伞切断ad大鼠海马erk升高，说明erk信号转导途径在AD发病早期有改变。
Conclusion: the level of ERK increased in hippocampus of rat model of AD, which showed changes of signal transduction route in the early phase.
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