目的:观察美洛昔康对慢性铝过负荷致大鼠神经元退变的保护作用及其机制。
Objective To study the protective effects and mechanisms of meloxicam on neurodegeneration induced by chronic aluminum overload in rats.
侧脑室微量注射氯化铝,一天1次,连续5天,建立铝负荷致小鼠神经元退变模型。
Methods(1) Neurodegenerative model of mice was established via intracerebroventricular injection of aluminum, once a day for 5 days.
结果(1)基因工程细胞可防止多巴胺能神经元退变死亡,与对照组比较,最多增加了95 4 %,P。
Results The number of dopaminergic neurons protected by engineered cells increased at least by 95.4% in comparison with the control cells (P<0.01).
应用推荐