目的研究抗真菌药物布替萘芬的体外抗真菌活性和对真菌麦角甾醇生物合成的影响。
Objective To study in vitro antifungal activity of butenafine and its effect on ergosterol biosynthesis in fungi.
胆甾醇、麦角甾醇和豆甾醇及其衍生物是真菌中的主要甾体化合物，具有重要的生理功能和生物学活性。
Cholesterol, ergosterol and stigmasterol and their derivatives are the major steroids in fungi with important physiological functions in fungi as well as biological activities on other organisms.
结论GC MS分析获满意的效果，可对抗真菌药物阻断真菌麦角甾醇合成通路所引起各甾醇组分的含量变化进行研究。
CONCLUSION the satisfactory results are obtained by GC MS analysis and it can be used to study the inhibition of antifungal agents on sterol biosynthesis with the shift in sterol composition.
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