...K)已成为目前研究进展最快,最受瞩目的NSCLC治疗靶点,吉非替尼、厄罗替尼作为常见的酪氨酸激酶抑制剂(tyrosine kinase inhibitors, TKIs),已广泛应用于治疗NSCLC晚期病人。TKIs的疗效与EGFR TK区是否存在突变以及突变类型有关。
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金雀异黄素是一种天然的酪氨酸激酶抑制剂,可以抑制多种肿瘤细胞的增殖,并诱发细胞凋亡。
Genistein, a natural tyrosine kinase inhibitor, has been reported to inhibit growth and induce apoptosis of various Turner cells.
Rigel的激酶抑制剂,称为fostamatinib,以脾酪氨酸激酶为目标。 其主要功能是可以让自身免疫疾病形成大型免疫细胞复合体。
Rigel's kinase inhibitor, called fostamatinib, targets spleen tyrosine kinase, which among other functions enables the formation of the large immune-cell complexes found in autoimmune diseases.
目的:对近年来酪氨酸激酶抑制剂的研究进展作以综述。
Objective: to review the progress in the research of tyrosine kinase inhibitors in recent years.
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