目前认为来自骨髓的血管内皮祖细胞(endothelial progenitor cell,EPC)是血管新生的主要细胞之一[3]。EPC可作为肿瘤患者预后的指标和治疗的靶标[4]。
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血管内皮祖细胞是一类能循环、增殖并能直接分化为血管内皮细胞的前体细胞。
Endothelial progenitor cell (EPC) is a subtype of progenitor cells that can circulate, proliferate and have the ability to differentiate into mature endothelial cells.
目的观察血管内皮生长因子受体1 (VEGFR1)阳性造血祖细胞与人大肠癌转移的关系及机制。
Objective to investigate the relation of vascular endothelial growth factor receptor 1 (VEGFR1) -positive hematopoietic progenitor cell with the metastasis of human colorectal carcinoma.
结论：体外扩增法成功地从兔骨髓中分离培养出具有血管内皮祖细胞特征的细胞群体。
CONCLUSION: Cell colony with the feature of EPCs can be isolated and cultured from rabbit bone marrow by in vitro amplification method successfully.
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