目的分析细胞周期素依赖激酶4 (CDK4)在颌骨软骨肉瘤的表达及意义。
AIM To analyze the expression and significance of cyclin dependent kinase 4 (CDK4) in chondrosarcoma of the jaws.
方法：采用多重聚合酶链反应方法，以提取的基因组d NA为模板，在同一反应管中同时扩增细胞周期素d 1基因和P 16基因。
METHODS: Method of multiplex polymerase chain reaction (PCR) was adopted. Cyclin D1 gene and P16 gene were amplified in the same tube, using extracted genome DNA as template.
结论：细胞周期素d1的扩增和P 16的缺失与肺癌细胞的高增殖活性密切相关。
CONCLUSION: the high amplification of Cyclin D1 and the high deletion of P16 gene is closely related to the high activity of proliferation of lung cancer.
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