“我们惊讶地得到了死亡受体，它不会对任何激素产生反应，因为以前那些同样的状态在蛋白质中只存在很短的时间。”桑顿说道。

"We were surprised to get a dead receptor that wouldn't respond to any hormones, because those same states had existed in the protein a relatively short time before," says Thornton.

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在此模型中，更高的临床肿瘤分级及雌激素受体阴性与远处复发或死亡存在具有显著统计学差异的相关性。

In this model, higher clinical tumor stage and ER-negative status were associated with a statistically significantly greater risk for distant relapse or death.

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近年来对凋亡发生和调控机制的研究表明，细胞凋亡途径主要有两条：线粒体途径和死亡受体途径。

In recent years, studies of occurrence and regulation mechanism of apoptosis show that the two major apoptotic pathways are the mitochondrial and death receptor pathways.

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