作者采用小鼠骨髓瘤细胞系与破伤风类毒素免疫的人外周血淋巴细胞进行融合,对影响人-鼠杂交瘤细胞制备人单抗成功的因素进行了探讨。
The cells from mouse myeloma cell line SP2/0 were fused with human peripheral blood lymphocytes from the donors primed with a conventional dosage of tetanus toxoid (TT).
还揭示表达所述免疫球蛋白分子和单克隆抗体的杂交瘤细胞或其他细胞系。
Hybridomas or other cell lines expressing such immunoglobulin molecules and monoclonal antibodies are also disclosed.
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