依赖于半胱氨酸蛋白酶的激活，美沙酮通过激活线粒体克服了白血病细胞中的阿霉素耐药、多药耐药、和凋亡抑制。

Depending on caspase activation, methadone overcomes doxorubicin resistance, multidrug resistance, and apoptosis resistance in leukemia cells through activation of mitochondria.

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目的多药耐药性是导致急性白血病化疗失败的主要原因。

Objective Multidrug resistance can eventually result in the chemotherapy failure of acute leukemia.

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目的研究多药耐药(MDR - 1)基因在急性白血病(AL)治疗中的表达。

Objective To study on the expression of multiple drug resistance (MDR 1) gene during treatment course of acute leukemia (AL).

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