目的考察乳酸-羟乙醇酸共聚物(PLGA)微球制备工艺对新城疫病毒的稳定性影响,并寻求合适的保护剂以稳定新城疫病毒的活性。
OBJECTIVE to evaluate the effects of formulation technique of PLGA microspheres on the stability of Newcastle disease virus and to look for a proper protectant to stabilize Newcastle disease virus.
根据冻干后外观、病毒滴度和热稳定性试验等结果,筛选出冻干保护剂的最适配方。
Screen the optimal stabilizer according to the appearance, virus titer and thermostability of the freeze-dried vaccine.
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