目的探讨大鼠心脏移植过程中，重组腺病毒介导的外源基因转移至供心的可行性及安全性。
Objective to study efficiency and security of the recombinant adenoviral-mediated gene transfer to the donor heart during the heart transplantation.
逆转录病毒介导的基因转移技术要过渡到临床应用，主要解决如何使病毒载体具有高滴度而不具有复制活性。
In order to use retroviral-mediated gene transfer technology in clinical application, retroviral vector must be of high titer and free of detectable replication-competent retroviruses.
结论逆转录病毒介导的基因转移系统是高效、安全的，有助于人类白血病的基因治疗研究。
Conclusion the efficiency and safety of the gene transfer system may provide an optimal experimental system in gene therapy for human leukemia.
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