美伐他汀是3羟甲基戊二酰辅酶a还原酶的有效的竞争性抑制剂，它是一种胆固醇生物合成调解酶。
Mevastatin is a potent competitive inhibitor of 3-hydroxy-3-methyl-glutaryl-coa reductase, a regulatory enzyme for cholesterol biosynthesis.
美伐他汀是3羟甲基戊二酰辅酶a还原酶的有效的竞争性抑制剂，它是一种胆固醇生物合成调解酶。
Mevastatin is a potent competitive inhibitor of 3-hydroxy-3-methyl-glutaryl (HMG) -coa reductase, a regulatory enzyme for cholesterol biosynthesis.
结论：普伐他汀不能抑制肝细胞PAI- 1的分泌。羟甲基戊二酰辅酶A还原酶的抑制与PAI- 1分泌可能没有关系。
Conclusion:Pravastatin can not inhibit the secretion of PAI 1 in hepatic cells and the inhibition of hydroxymethylglutaryl coenzyme A reductase may not be related to the secretion of PAI 1.
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