UVB射线照射皮肤产生活性氧簇并引发炎症级联反应(inflammatory cascade),诱发皮肤出现红斑。大豆异黄酮和大豆染料木素已经显示出潜在的抗癌作用和防光老化作用。
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LPS can stimulates endothelium,macrophage and neutrophil,the 3 main targets,producing a large number of cytokine,which leads to inflammatory cascade reaction out of control,and leads to endotoxin shock,tissue damage and multiple organ dysfunction syndrome at last.
LPS广泛作用于机体多种组织器官,其中内皮细胞、巨噬细胞和中性粒细胞是最主要的效应细胞,在LPS的刺激下,它们产生大量的细胞因子,即“细胞因子风暴”(cytokine storm),进而引起失控性的炎症级联反应,最终引起内毒素休克、组织损伤和多器官功能障碍(mutiple organ dysfunction,MOD)。
参考来源 - 内毒素休克小鼠肝脏细胞质磷酸化蛋白质组学的研究·2,447,543篇论文数据,部分数据来源于NoteExpress
结论亚低温对缺血脑组织具有保护作用,对炎症级联反应的抑制可能是其发挥脑保护作用的重要机制之一。
Conclusion Mild hypothermia has a protective role in cerebral ischemic tissue and inhibits the inflammatory cascade reaction, which may be one of the neuroprotective role mechanisms.
当合胞体滋养层细胞死亡,他们就会释放到母体的血液循环中,从而引起炎症级联反应,进而损害母体的器官。
When syncytiotrophoblast cells die, they are released into the maternal circulation, initiating a cascade of inflammation that can damage maternal organs.
RAS抑制可以通过多种分子机制抑制肺泡上皮细胞和血管内皮细胞的凋亡,抑制炎症级联反应和细胞外基质沉积,而使肺纤维化病变减轻。
RAS inhibition can reduce cell apoptosis of alveolar epithelial cells and endothelial cells, interfere with the inflammation cascade, and decrease fibroblast activity during tissue repair process.
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