外消旋体拆分是获取单一对映体药物的主要方法,将主客化学引入化学拆分发明的包结拆分法突破了经典拆分方法的局限;
The main method used to obtain monoenantiotropic drugs is resolution of raceme. Resolution inclusion method breaks through the limitation of classical resolutions by introducing host guest chemistry.
在许多情况下,外消旋药物中的单一对映体分别具有不同的疗效,有的甚至有相反的作用。
In many cases, racemic drug's single antipode has different curative effect, sometimes it even has adverse action.
当手性药物以外消旋体供药用时,其对映体间就可能发生药效学和药代动力学的相互作用。
Pharmacological interactions between the enantiomers may happen when a chiral drug was used as its racemate.
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