皮疹的变化从斑丘疹(底部扁平的病变)，一直到小水疱(充满液体的小疱)、脓疱，大约10天左右伴随而来的便是结痂。
Evolution of the rash from maculopapules (lesions with a flat bases) to vesicles (small fluid-filled blisters), pustules, followed by crusts occurs in approximately 10 days.
Marcinak医学博士及其同事写道，“这病例强调当评估最近的种痘患者及其有水疱脓疱皮疹的家庭成员时医师要保持高度怀疑的心理指标。”
This case highlights the need for clinicians to maintain a high index of suspicion when evaluating recently vaccinated patients and their family members with vesiculopustular rash.
大疱为圆形或不规则形的大水疱，含浆液性浆液脓性液体，大于1cm，与水疱仅是大小之别。
Bullae are rounded or irregularly shaped blisters containing serous or seropurulent fluid. They differ from vesicles only in size, being larger than 1 cm.
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