为了进一步验证其疗效，明确其作用机制，我们又观察了其对氨基核苷嘌呤霉素(puromycin aminonucleoside，PAN)诱导的大鼠实验性肾炎的治疗作用。
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氨基核苷嘌呤霉素肾炎 puromycin aminonucleoside nephritis
氨基核苷嘌呤霉素是合成嘌呤毒素的半合成类似物中关键性的中间体。
Puromycin aminonucleoside is the key intermediate in the synthesis of semi-synthetic analogues of puromycin.
氨基核苷嘌呤霉素诱导肾病变是人原发性肾病综合症的模型，抑制培养的肾小球上皮细胞整联蛋白的表达。
Puromycin aminonucleoside-induced nephrosis is a well-described model of human idiopathic nephrotic syndrome, suppressing expression of integrin expression in cultured glomerular epithelial cells.
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