结论COPD急性加重期较稳定期肺功能显著下降，肺过度充气和外周气道阻力增加是急性加重期肺功能恶化的主要原因。
Conclusions Pulmonary function of COPD decreased significantly from stable stage to exacerbation, the main reasons of which were hyperinflation and the increasing of peripheral airway resistance.
SR140333不影响正常对照组豚鼠的咳嗽反应，而SR48968则可降低咳嗽频率达30%（P<0.05），两者均抑制吸入辣椒素后增加的气道阻力。
SR48968FR decreased the cough response by 30% in control guinea pigs (P<0.05), but SR140333 did not. Both prevented an increase in airway resistance after the inhalation of capsaicin.
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