乏颗粒细胞层（stra-tum granulosum）阻止棘层细胞（prickie cell）间隙内组织液外溢能力也下降这些生理变化造成了：皮肤松弛、易成褶和沟纹如产生眼睑、眼袋、
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水泡上方及附近的棘层细胞；
BP, found in spinous layer cells attached on the blisters or nearby.
本型组织病理改变，主要是表皮角质层有显著角化不全，棘细胞层增厚，表皮突向下延展，深入真皮。
Pathological changes of the organization, mainly the epidermal cuticle significant parakeratosis, acanthosis cell layer thickening, epidermal sudden downward extension of in-depth dermis.
结果表皮生长因子阳性染色细胞主要分布于棘层和颗粒层。
The results showed that the EGF positive staining cells were mainly localized in the stratum spinosum and stratum granulosum.
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