所以多数学者主张术中或术后早期腹腔内化疗(early postoperative intraperitoneal chemotherapy EPIC),而且术后早期病人的宿主防御系统受手术及麻醉的打击,处于最差状态,需要加强治疗来弥补这一缺陷。
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结果表阿霉素在术后早期腹腔内化疗时腹腔液峰值浓度比外周静脉高228倍,且持续时间长;腹腔液总平均浓度比外周静脉高167倍。
Results: the peak and the mean levels of epirubicin in the peritoneal fluid were 228 and 167 times higher than the corresponding peripheral vein levels.
术中或术后早期应给辅助性腹腔内化疗,并配合放疗及BRM辅助治疗。
Intraoperative or postoperative adjuvant to be intraperitoneal chemotherapy, and radiotherapy and BRM with adjuvant therapy.
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