但什么是这些药物的最佳剂量，最大耐受剂量，最大限度抑制目标的最小剂量？
The maximum tolerated dose? The minimum dose that leads to maximum inhibition of the target?
本文综述关于I期临床试验的研究。主要介绍确定最大耐受剂量（MTD）的不同方法，以及提出可以进一步进行研究的问题。
This paper summarizes studies for phase I clinical trials. It mainly introduces different, methods about determining maximum tolerated dose(MTD) and proposes further subjects for future research.
这篇论文主要研究的是第i阶段临床试验中最大耐受剂量的估计问题。
In this paper, the estimation of the maximum tolerated dose of a drug for phase I clinical trials is investigated.
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