结果：6厂家替硝唑片的溶出速率相差很大（P<0.01）。

Results:There were significant differences in dissolubility among the products from 6 factories(P<0.01).

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塞克硝唑片组实验室检查异常发生率为0.00%，替硝唑片组实验室检查异常发生率为2.08%，两组之间比较差异无统计学意义（P>0.05）。

The rates of abnormal results of laboratory test were 0.00% in trial group and 2.08% in control group. There were no significant differences between two groups in safety(P>0.05).

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目的通过星点设计-效应面法优化替硝唑结肠靶向生物黏附片处方。

OBJECTIVE To optimize the formulation of tinidazole colon-targeted bioadhesive tablets by the central composite design-response surface methodology (RSM plus CCD).

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