这是一个充满困难和挫折的时期。

It was a time fraught with difficulties and frustration.

《牛津词典》

这种不管障碍和挫折的锲而不舍的能力是人们最为钦佩的品质。

This ability to persevere despite obstacles and setbacks is the quality people most admire in others.

《柯林斯英汉双解大词典》

当然也有挫折的时候：她经常是比赛的最后一名游泳选手。

There were moments of frustration of course: often she would be the last swimmer in the race.

youdao

I don't want you to get all frustrated and fail to show what you know, so here are a couple of tips.

我不希望你受到挫折,由于失败而不能体现你所知道的，因此这儿有一些小提示。

麻省理工公开课 - 固态化学导论课程节选

They think, I'm really a smart investor, I figured it out,; it can reinforce the behavior until they get to maybe some terrible end.

他们会想我真是个聪明的投资人,我制定了如此有效的投资策略,这种想法使他们的自我膨胀加剧,直到他们遇到挫折或打击

耶鲁公开课 - 金融市场课程节选

Plato's desire for a kind of radical makeover, of Athenian and Greek political institutions and cultures, grew out of his experience of political defeat and despair.

柏拉图想要彻底改变，雅典及希腊,政治制度及文化的欲望，来自他的,政治挫折及失望。

耶鲁公开课 - 政治哲学导论课程节选