HCV感染持续及其并发症，最佳的成效是根除感染。因此，治疗应答常常以HCV RNA的检测结果为标志。出现持续的病毒学应答（sustained virologic response，SVR）时，认为病毒已被清除，其标准是用敏感的检测方法，在治疗结束时以及6个月之后，血清中HCV RNA已不
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在两项试验中，持续的病毒学应答率为79%和80%，相比标准治疗方案，即长效干扰素联合利巴韦林的应答率50%更高。
The sustained virologic response rate was 79% and 80% in two studies, which was higher than the response rate of 50% with the standard of care with peginterferon plus ribavirin.
持续病毒学应答可以降低肝硬化和肝病并发症的发生，降低肝癌(肝细胞性癌)和死亡的发生率。
Sustained virologic response can result in decreased cirrhosis and complications of liver disease, decreased rates of liver cancer (hepatocellular carcinoma), and decreased mortality.
持续性病毒学应答的最佳指标是较低的治疗前血清hbv DNA滴度和较高的谷丙转氨酶(ALT)水平。
The best indicators of sustained virologic response are low pre-treatment serum HBV DNA titers and elevated alanine aminotransferase (ALT) levels.
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