我最大的问题是我现在很忙。

My biggest problem is that I am too busy.

youdao

我最大的问题是读和写。

My biggest problems are reading and writing.

youdao

我最大的问题是人们总是误解我，认为我很有攻击性。

My biggest problem is that people always misinterpret me as being aggressive.

youdao

But I see our biggest threats are the implosion of the whole Middle East, to start with.

我认为我们面临的最大威胁,首先是中东问题。

普林斯顿公开课 - 国际座谈会课程节选

I had an injury as well, so I couldn't stand. That was my big problem.

我受过伤，所以我不能站着。这是我最大的问题。

记忆犹新的作品 - SpeakingMax英语口语达人