方法：采用前瞻性的随机对照研究。

Methods: The prospective randomized control trial is used.

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前瞻性的随机对照研究。

Study Design. A prospective, randomized controlled trial.

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检索到与临床功效和安全性相关的两个随机对照试验(rct)、一个前后对照研究、两个回顾性报告，以及18个药物动力学研究。

Two randomized controlled trials (RCTs), one before-and-after study and two retrospective reports on clinical efficacy and safety were retrieved, together with 18 pharmacokinetic studies.

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