此后，COX - 2抑制剂和传统的NSAIDs在心血管安全性方面一直备受争议。
Since then, there has been much debate about the cardiovascular safety of COX-2 inhibitors and traditional NSAIDs, which several studies have not been able to resolve.
新指南适用于所有未被批准的药物，但代理商以另一个指南文件来评估已批准药物的心血管安全性。
The new guidance applies to all unapproved drugs, but the agency is working on another guidance document to evaluate the cardiovascular safety of drugs already approved.
《国际糖尿病》：这是一个非常重要的话题不是么？对新的抗糖尿病药物的心血管安全性的关注很多。
International Diabetes: This is a very important topic is it not? There is a lot of focus on cardiovascular safety for new anti-diabetic drugs.
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