MCM复合体被认为是一种复制解旋酶，而pre-RC的形成参与染色质许可。

The MCM complex is thought to be the replicative helicase, and formation of the pre-RC is referred to as chromatin licensing.

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前复制复合体（Pre-RC）在有丝分裂末期/G1早期随着CDT1和cdc6的结合而形成，允许异源六聚化的MCM2-7复合体的结合。

The pre-replication complex (Pre-RC) forms in late mitosis/early G1 phase beginning with the binding of CDT1 and cdc6 to the origin, which allows binding of the heterohexameric MCM2-7 complex.

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通过cdk2磷酸化的cdc6阻止其降解，允许前复制复合体的形成（5）。

Phosphorylation of cdc6 by cdk2 prevents its degradation, allowing pre-replication complexes to form (5).

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