为探讨超急排斥反应(Hyperacute rejection,HAR)及延迟性异种排斥反应(Delayed xenograft rejection,DXR)的分子调控机制,采用优 ..
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...腺修饰可通过抑制受体(猴)T细胞的识别与增殖，减轻供心VECs激活，最终缓解延迟性异种排斥反应(Delayed Xenograft Rejection，DXR)，从而使供心存活时间显著延长，但不能完全克服DXR。
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及延迟性异种排斥反应 Delayed xenograft rejection
研究表明，异种移植物引起的延迟性异种排斥反应与内皮细胞活化有关。
In this setting, xenografts elicit severe and acute rejection linked to endothelial-cell activation.
结论异种移植发生延迟性排斥反应时，P选择素和ICAM - 1均有表达，可以作为判断异种移植免疫抑制治疗效果的指标之一。
Conclusion the expression of P-selectin and ICAM-1 in xenografts was increased during delayed xenograft rejection, which is of value in judging the effect of immunosuppression in xenotransplantation.
在豚鼠—大鼠异种心脏移植中，给以眼镜蛇毒因子以避免发生超急性排斥反应，制作延迟性排斥反应模型。
In guinea pig to rat heart xenotransplantation model, cobra venom factor is administrated to avoid hyperacute rejection, and thus delayed xenograft rejection model is made.
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