DN早期表现为肾小球内高血压、高灌注、高滤过，进而出现肾小球毛细血管袢基底膜(glomerular basement membrane，GBM)增厚和系膜基质(extracelIular matrix，ECM)增多，最终导致肾小球硬化。
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电镜图示，由于免疫复合物沉积在肾小球毛细血管袢中，使基底膜增厚（箭头）。
The thickened basement membrane (arrow) that results from immune complex deposition in the glomerular capillary loop is prominent in this electron micrograph.
病理表现为系膜基质增多，肾小球基底膜上皮下透明物质积聚以及毛细血管袢与包氏囊粘连等改变。
The pathological character shows that messegium increased, transparency material of the glomerulus basement membrane epithelium accumulates, capillary and capsular adheres.
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