结论：趋化因子CXCL12、受体CXCR4和CXCL12—CXCR4生物学轴在肿瘤转移中发挥着重要的作用。

Conclusion: The chemokine factor CXCL12, its receptor CXCR4 and biological axis of CXCL12-CXCR4 play important roles in tumor metastasis.

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它们的这些生物学功能是通过配体与受体结合的方式来发挥的，而CXCR3与CCR5是RA中趋化因子的标志性受体。

All of these biological effects are performed by binding of ligands to receptors. Elsewhere, CXCR3 and CCR5 are mark chemokine receptors in RA.

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