大剂量甲氨蝶呤（high-dose methotrexate，HDMTX）是治疗儿童急性淋巴细胞白血病和髓外白血病预防的主要措施，防治效果与MTX用量有关。
基于26个网页-相关网页
大剂量甲氨蝶呤治疗急性淋巴细胞性白血病的护理- 急性淋巴细胞性白血病(acute lymphoblastic leukemia,ALL)的主要手段。大剂量甲氨蝶呤(highdosage methotrexate,HDMTX)是ALL巩固和强化治疗的重要方案之一。笔者应用HDMTX治疗ALL患者,通过有效的护理干预,预防和减
基于4个网页-相关网页
...蝶呤治疗儿童急性淋巴细胞白血病的疗效与安全性分析 孟岩 【摘要】： 目的:大剂量甲氨蝶呤(high-dose methotrexate , HD-MTX)是儿童急性淋巴细胞白血病(Acute lymphoblastic leukemia, ALL,简称急...
基于2个网页-相关网页
... 注射用甲氨蝶呤 Methotrexate for Inj ; METHOTREXATE FOR INJECTION 大剂量甲氨蝶呤 MTX 二氯甲氨蝶呤 dichioromethotrexate ...
基于1个网页-相关网页
BACKGROUND &OBJECTIVE:High-dose methotrexate (HDMTX), which interrupts folate metabolism, is used in the treatment of acute lymphoblastic leukemia (ALL), but exerts different toxic effects in ALL patients received the same dose MTX.
研究背景与目的:大剂量甲氨蝶呤(MTX)是急性淋巴细胞白血病(ALL)重要的治疗药物,相同剂量的MTX用于不同患者产生的毒副反应各异,机制尚未阐明。
参考来源 - MTHFR基因、CASP8基因遗传多态性与急性淋巴细胞白血病ConlusionThis study established the detabase about the therapy of high-dose MTX in children with acute lymphoblastic leukemia,Population pharmacokinetics model equtation were made through NONMEM,and Get Population pharmacokinetics parameters which can offer important indicatrix for MTX clinical individualized treatment.
结论本研究建立了儿童急性淋巴细胞白血病患者大剂量甲氨蝶呤治疗的群体数据库,通过NONMEM法建立了群体药物动力学模型方程,得到了相对全面的群体药物动力学参数,为临床甲氨蝶呤的个体化治疗提供了重要的依据。
参考来源 - 大剂量MTX在急性淋巴细胞白血病患儿体内的群体药物动力学研究·2,447,543篇论文数据，部分数据来源于NoteExpress
结果大剂量甲氨蝶呤化疗符合二室模型分布特征。
RESULTS The pharmacokinetics of high dose methotrexate were described by a two-compartment model.
目的：研究大剂量甲氨蝶呤(HDMTX)治疗儿童急性淋巴性白血病的疗效。
Objective: To research about treatment of children ALL with high dose MTX and its therapeutic outcome.
目的：通过血药浓度监测，提高对小儿急性淋巴细胞白血病大剂量甲氨蝶呤化疗的有效性和安全性。
OBJECTIVE: to improve the efficacy and safety of high dose methotrexate (HDMTX) chemotherapy in the treatment of children with acute lymphoblastic leukemia through blood concentration monitoring.
应用推荐