随着生物技术与多肽合成技术的日臻成熟，越来越多的多肽药物被开发并应用于临床。因适应证广、安全性高且疗效显著，多肽药物目前已广泛应用于肿瘤、肝炎、糖尿病、艾滋病等疾病的预防、诊断和治疗，具有广阔的开发前景。
... 多肽药物 polypeptide drugs 白蛋白多肽 albumin polypeptide 苦瓜多肽 polypeptidek ...
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生命科学 关键词： 蛋白质；多肽药物；长效性；给药系统；定点突变；化学修饰 [gap=930]Key words: protein; peptide drugs; long acting proteins; drug delivery systems; site-specific mutagenesis; chemic..
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The polymer-based microsphere dosage forms successfully applied in sustained-release delivery of peptide drugs become no longer feasible for protein drugs due to the fragile higher structure of these macromolecules and adverse immune response induced by their structural changes.
成功地用于多肽药物的聚合物缓释微球技术至今未能成功地应用于蛋白药物,主要是蛋白分子的高级结构在制剂过程中脆弱易变、失活甚至导致有害的免疫反应。
参考来源 - PLGA缓释微球制备条件对蛋白药物活性及免疫原性的影响·2,447,543篇论文数据，部分数据来源于NoteExpress
本发明属于生物化学中的多肽药物技术领域。
The present invention belongs to the field of polypeptide medicine technology in biochemistry.
转铁蛋白作为一种药物载体，在蛋白多肽药物的口服给药领域有着美好前景。
The utilization of transferrin as a carrier in peptide and protein peroral drug delivery is a promising approach.
本文概述了近年来转铁蛋白在蛋白多肽药物口服给药中的作用及有关转运机制的研究进展。
In this paper, the progress of transferrin applied in protein and peptide peroral delivery is reviewed, and the transportation mechanism of transferrin is also discussed.
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